Temazepam may well lessen the excretion level of Acetaminophen which could cause an increased serum amount.apalutamide will decrease the extent or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medication which have been CYP2C19